�AstraZeneca welcomes the recommendations by the National Institute for Health and Clinical Excellence (NICE) on the treatment of Familial Hypercholesterolaemia (FH) 1, a genetical condition resulting in high cholesterol levels. As region of its comprehensive review on the identification and management of people with FH, NICE has recommended that adults with the condition be treated with high chroma statins in order to reduce LDL-cholesterol (LDL-C) levels by 50%.
Michael Livingston, Director of H.E.A.R.T UK - The Cholesterol Charity, stated: "About nonpareil person in every D has FH in the UK - in fact it's unitary of the most often occurring transmissible conditions. This means that more than 110,000 people in Britain experience the condition. However, many people with FH go undetected with often tragic consequences. The next step for us will be to secure this steering is enforced on the ground".
People with FH have a substantially increased cardiovascular risk in comparing with the general population, due to their elevated cholesterol levels, which stool sometimes be in excess of 20 mmol/l. The average number cholesterol degree for center aged manpower is about 5 mmol/l. Men with FH have a greater than 50% chance of developing coronary heart disease (CHD) by the time they reach 50. Women with FH face a 30% CHD risk by the prison term they hit 601. Comprehensive trial information from large clinical trials has shown that there is a linear relationship between the absolute reductions in LDL-C and the proportional reducing of coronary and other events. Lowering LDL-C by 1mmol/l reduces cardiovascular disease related events (including spirit attack and stroke) by 21% and total mortality by 12%.
Dr Elizabeth Hughes, Consultant Chemical Pathologist and Honorary Senior Lecturer at the University of Birmingham, commented: "Too often patients are put on generic zocor, when first-class honours degree diagnosed with FH, only to throw to keep going for repeat blood tests and consultations until they ar eventually stirred onto a more effective, higher intensity statin which in reality means either rosuvastatin or atorvastatin. This guidance has recognised that some adults with FH need to be put onto a high vividness statin immediately, particularly if their LDL-C levels pauperism to be reduced by more than half".
When choosing which high intensiveness statin therapy is the most allow for the individual patient, clinicians should take into account the patient's informed preference, comorbidities, multiple do drugs therapy, and the benefits and risks of treatment. CRESTOR (rosuvastatin) has been shown to be extremely effective at helping patients reduce their LDL-C levels. In o'er 15 neck and neck studies involving more than 12,000 patients, rosuvastatin has consistently demonstrated better LDL-C letting down in comparing with lipitor and simvastatin across the dose ambit.
The guideline makes a range of other recommendations on the identification and management of people with FH including the use of cascade testing to identify those individuals wHO will benefit from early treatment and the recommendation that doctors should provide patients with evidence-based info, such as the treatments that are currently available, lifestyle advice and how the FH may affect other members of the family.
About CRESTOR
CRESTOR has now standard regulatory approvals in over 90 countries. Over 12 million patients have been prescribed CRESTOR worldwide. Data from clinical trials and real human beings use shows that the safety profile for CRESTOR is in line with other marketed statins.
About AstraZeneca
AstraZeneca is a major international health care business busy in the research, exploitation, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the world's leading pharmaceutical companies with healthcare gross revenue of $26.47 one thousand million and starring positions in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infection products. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4 Good Index.
http://www.astrazeneca.com
View drug data on Crestor.
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Tuesday, 2 September 2008
Saturday, 23 August 2008
Download Miki Howard mp3
 Artist: Miki Howard: mp3 download Genre(s): R&B: Soul Discography:  Three Wishes Year: 2001 Tracks: 10 Miki Howard grew up in the church, where both of her parents were gospel singers. Her mother was besides a appendage of the religious doctrine chemic group the Caravans and was acquainted with divers entertainers. Howard's mother would assume her to the homes of diverse stars such as Aretha Franklin and Mavis Staples. While still in elementary school day, Howard moved to Los Angeles with her ma. At the age of 15, she performed in a adolescent pageant. After the show, she met Side Effect member Augie Johnson, world Health Organization happened to be in the hearing and began working with Howard creatively. After a period of time, Howard became a Side Effect member -- upon the deviation of Sylvia St. James. Howard's tenure with the chemical group lasted a few age. During this time, she too had iI children by Johnson. In addition to vocalizing with Side Effect, she did background vocals for Wayne Henderson, Roy Ayers, Stanley Turrentine, and several other artists. Subsequently leaving Side Effect, Howard signed a deal with Atlantic. Her first-class honours degree reach for the pronounce was the Billboard R&B Top Ten single "Come Share My Love." She followed that with the remaking of Glenn Miller's 1940 hit "Resource." Her success continued with iI more than Top Ten singles, "Baby Be Mine" and "That's What Love Is." The latter was a duet with Gerald Levert and was the event of the originative matrimony Howard formed with Marc Gordon and Levert. Howard and Levert later became romantically involved, and that romance spawned one of Howard's biggest hits, "Love Under New Management." The song was written during their abbreviated love social occasion, only was released after their romance had dissolved. In 1990, Howard signed a deal with Giant, which facilitated the dismission of her number one smash gain "Ain't Nobody Like You." Howard's life line at Giant was cut short due to an affray her married man had at the pronounce. She likewise made an appearance as Billie Holiday in a club conniption in the Spike Lee moving picture Malcom X. Howard continued to way out albums throughout the '90s and early 2000s, a few of them heavy on -- or wholly reliant upon -- covers. Her releases during these age included Femme Fatale (1992), Shining Through (1993), Live Plus (1996), Can't Count Me Out (1997), Troika Wishes (2001), and Pillow Talk (2006). |
Wednesday, 13 August 2008
Minogue sisters duet for TV theme tune
Kylie and Dannii Minogue will couplet on a theme tune for a new BBC Two comedy series.
According to The Sun, the sisters have recorded a cover of Abba's 'The Winner Takes It All'.
The track will apparently soundtrack the opening credits for Jonathan Harvey's fresh sitcom Beautiful People.
Harvey's committal to writing credits admit Coronation Street, Gimme, Gimme, Gimme and The Catherine Tate Show.
Meera Syal will star in the show, which is based on the puerility of British writer Simon Doonan, world Health Organization currently plant as a designer in New York.
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According to The Sun, the sisters have recorded a cover of Abba's 'The Winner Takes It All'.
The track will apparently soundtrack the opening credits for Jonathan Harvey's fresh sitcom Beautiful People.
Harvey's committal to writing credits admit Coronation Street, Gimme, Gimme, Gimme and The Catherine Tate Show.
Meera Syal will star in the show, which is based on the puerility of British writer Simon Doonan, world Health Organization currently plant as a designer in New York.
More info
Wednesday, 6 August 2008
Thursday, 26 June 2008
Blu Cantrell - Fascinating Fact 5437
R+B star BLU CANTRELL has reportedly agreed to pose naked for Playboy magazine after shedding upwards of 25 pounds (11.3 kilograms) while training for new U.S. TV reality show CELEBRITY CIRCUS.
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Wednesday, 18 June 2008
Vancouver's classic wooden roller coaster celebrates 50 years
VANCOUVER - The first drop is the best - or the worst, depending on how you look at it.
One of a few remaining wooden roller-coasters still in working order, Vancouver's classic coaster celebrated its 50th anniversary Tuesday.
The old-fashioned scream machine reaches speeds of more than 70 kilometres per hour after dipping over its first hill, prompting shrill cries from riders as they plummet down the track and bounce around in their seats.
"It's my favourite ride," Ariana Louwe, 16, said after taking a free ride as the Pacific National Exhibition celebrated the anniversary.
"The first hill is the best, definitely, it's really fast. It's not so much scary, just exciting."
The ride - simply named The Coaster - was built in 1958, and now sees half a million riders each year.
It's made from Douglas fir wood and stands 23 metres tall at its highest point.
The 90-second ride is mostly powered by gravity. The trains are pulled by a chain on a motor up each slope, allowing momentum to carry forward to the base of the next big climb.
As the trains twist through the track, riders are held in only by a lap bar, compared with the seatbelts and snug shoulder restraints on modern-day roller-coasters.
And while Vancouver's wooden coaster doesn't go upside-down or travel at the same break-neck speeds as its modern-day steel cousins, riders say it still provides a thrill.
"It's got great hills and it's got great curves," said Paul Kool, 47. "Growing up here, I remember wanting to ride it ever since I was not tall enough to ride it."
Ulyana Yordan, a 31-year-old Ukrainian currently studying in Vancouver, rode the roller-coaster more than two dozen times Tuesday.
"I love it - we don't have such roller-coasters in Ukraine," she said. "I like how you fly around, because in other ones you are fully fixed, you don't feel it as much."
The ride was designed by Carl Phare and built by Walker LeRoy. It's now the only standing roller-coaster built and designed by Phare and LeRoy, who are legendary in the coaster world.
Phare's daughter, Nina Faley, and granddaughter, Jennifer Juelich, attended the anniversary ceremony.
Faley rode her first roller-coaster when she was just two years old, one of Phare's creations at his own amusement park, Seattle's Playland, which closed more than 40 years ago. She said she was happy to see one of his coasters still standing.
"I can't tell you how glad I am," said Faley, before taking a ride herself.
"And we're really glad that it's going to last another 50 years, hopefully," added Juelich. "Because he might not be here physically, but his spirit is making hundreds of thousands of people really happy."
A few years ago, the city talked about relocating the amusement park, leaving some worried that a move could mean the end.
American Coaster Enthusiasts, a U.S.-based group devoted to the rides, listed The Coaster as "endangered."
But the relocation plans have since fizzled away, and the city's deputy mayor, Suzanne Anton, said it isn't going anywhere.
"This historic roller-coaster, with all its creaks and groans and stomach-stopping excitement - it has to stay here for another 50 years," said Anton.
Steve Gzesh of American Coaster Enthusiasts said Vancouver's wooden roller-coaster is one of the best in the world.
"It doesn't look like much from the street, but let me tell you, it delivers every time you ride it," he said.
"One of the things that many coaster enthusiasts really adore is air time, that sensation that you're lifted up out of your seat, and this coaster does it on every single drop. It's just phenomenal."
News from �The Canadian Press, 2008
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Monday, 9 June 2008
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